•  
  •  
 

Jurnal Keolahragaan

Keywords

exercise, sport, immunity, immune response, cytokine

Document Type

Article

Abstract

Physical exercise contributes to maintain our health, through its role in inflammatory immune response. Cytokines are proteins that mediate communication between immune cells, either as pro- or anti-inflammation agents. Nonetheless, the dominance of pro- over anti-inflammatory cytokines during a workout, is harmful to health. This systematic review aimed at determining the effect of physical activity in modulating pro- and anti-inflammatory cytokines during immune response. Following Preferred Reporting Items for Systematic Reviews (PRISMA) guideline, literature searching was conducted in 3 databases which were PUBMED/MEDLINE, DOAJ and GARUDA, using keywords, citation tracking and snowballing. Inclusion and exclusion criterias were used to screen, while the Newcastle Ottawa Scale (NOS) was used to assess the quality of the articles. Data extraction and analysis were conducted descriptively. There were 376 articles identified, of which 329 were sorted and 82 were retrieved. Thirty articles underwent quality assessment, resulting to 12 inclusion studies. In conclusion, physical exercise influences the modulation of cytokine, whereby IL-6 and TNF-α (pro-) which increase at the beginning of exercise, are balanced by the increase of IL-10 (anti-inflammatory), which appears later in exercise or during recovery. For this purpose, physical exercise is recommended as a combination of aerobic and resistance exercise performed regularly at moderate intensity.

Page Range

247-257

Issue

2

Volume

10

Digital Object Identifier (DOI)

10.21831/jk.v10i2.51677

Source

https://journal.uny.ac.id/index.php/jolahraga/article/view/51677

References

Abd El-Kader, Shehab M., Al-Jiffri, O. H., & Al-Shreef, F. M. (2016). Plasma inflammatory biomarkers response to aerobic versus resisted exercise training for chronic obstructive pulmonary disease patients. African Health Sciences, 16(2), 507-515. https://doi.org/10.4314/ahs.v16i2.19

Abd El-Kader, Shehab M., & Al-Shreef, F. M. (2018). Inflammatory cytokines and immune system modulation by aerobic versus resisted exercise training for elderly. African Health Sciences, 18(1), 120-131. https://doi.org/10.4314/ahs.v18i1.16

Abd El-Kader, Shehab Mahmoud, Gari, A. M., & Salah El-Den, A. E. M. (2013). Impact of moderate versus mild aerobic exercise training on inflammatory cytokines in obese type 2 diabetic patients: A randomized clinical trial. African Health Sciences, 13(4), 857-863. https://doi.org/10.4314/ahs.v13i4.1

Adijaya, O., & Bakti, A. P. (2021). Peningkatan sistem imunitas tubuh dalam menghadapi pandemi covid-19. Jurnal Kesehatan Olahraga, 51-60.

Bachi, A. L. L., Barros, M. P., Vieira, R. P., Rocha, G. A., De Andrade, P. B. M., Victorino, A. B., Ramos, L. R., Gravina, C. F., Lopes, J. D., Vaisberg, M., & Maranhão, R. C. (2019). Combined exercise training performed by elderly women reduces redox indexes and proinflammatory cytokines related to atherogenesis. Oxidative Medicine and Cellular Longevity, 2019, 1-9. https://doi.org/10.1155/2019/6469213

Bloigu, R., Bloigu, A., & Juvonen, T. (2020). Serum calprotectin, a marker of neutrophil activation , and other mediators of in flammation in response to various types of extreme physical exertion in healthy volunteers. Journal of Inflammation Research, 2020, 223-231

Despeghel, M., Reichel, T., Zander, J., Krüger, K., & Weyh, C. (2021). Effects of a 6 week low"dose combined resistance and endurance training on t cells and systemic inflammation in the elderly. Cells, 10(4). https://doi.org/10.3390/cells10040843

El-Kader, S. M. A., & Al-Jiffri, O. H. (2019). Aerobic exercise modulates cytokine profile and sleep quality in elderly. African Health Sciences, 19(2), 2198-2207. https://doi.org/10.4314/ahs.v19i2.45

Fitria, A., Lubis, L., & Purba, A. (2021). Pengaruh senam jantung sehat seri-i terhadap daya tahan jantung-paru, kekuatan otot dan kadar TNF-α plasma pada lanjut usia. Jurnal Ilmu Faal Olahraga Indonesia, 2(2), 34. https://doi.org/10.51671/jifo.v2i2.100

Fonseca, T. R., Mendes, T. T., Ramos, G. P., Cabido, C. E. T., Morandi, R. F., Ferraz, F. O., Miranda, A. S., Mendonça, V. A., Teixeira, A. L., Silami-Garcia, E., Nunes-Silva, A., & Teixeira, M. M. (2021). Aerobic training modulates the increase in plasma concentrations of cytokines in response to a session of exercise. Journal of Environmental and Public Health, 2021. https://doi.org/10.1155/2021/1304139

Hayati, H. (2014). Dampak latihan intensitas berat pada fungsi imun tubuh. Embrio, 4, 50-56. https://doi.org/10.36456/embrio.vol4.no0.a1234

He, Z., Tian, Y., Valenzuela, P. L., Huang, C., Zhao, J., Hong, P., He, Z., Yin, S., & Lucia, A. (2018). Myokine response to high-intensity interval vs. Resistance exercise: an individual approach. Frontiers in Physiology, 9(December), 1-13. https://doi.org/10.3389/fphys.2018.01735

Lundberg, T. R., Fernandez-Gonzalo, R., Tesch, P. A., Rullman, E., & Gustafsson, T. (2016). Aerobic exercise augments muscle transcriptome profile of resistance exercise. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 310(11), R1279-R1287. https://doi.org/10.1152/ajpregu.00035.2016

Maulana, R., Rochmania, A., Pendidikan, J., Olahraga, K., Olahraga, F. I., & Surabaya, U. N. (2020). Hubungan intensitas latihan dengan imunitas. Jurnal Prestasi Olahraga, 1(1), 20-35

Middelbeek, R. J. W., Motiani, P., Brandt, N., Nigro, P., Zheng, J., Virtanen, K. A., Kalliokoski, K. K., Hannukainen, J. C., & Goodyear, L. J. (2021). Exercise intensity regulates cytokine and klotho responses in men. Nutrition and Diabetes, 11(1). https://doi.org/10.1038/s41387-020-00144-x

Miles, L. (2007). Physical activity and health. British Nutrition Foundation Nutrition Bulletin, 32, 314-363

Nielsen, H. G., Øktedalen, O., Opstad, P.-K., & Lyberg, T. (2016). Plasma cytokine profiles in long-term strenuous exercise. Journal of Sports Medicine, 2016, 1-7. https://doi.org/10.1155/2016/7186137

Ostrowski, K., Rohde, T., Asp, S., Schjerling, P., & Pedersen, B. K. (1999). Pro- and anti-inflammatory cytokine balance in strenuous exercise in humans. Journal of Physiology, 515(1), 287-291. https://doi.org/10.1111/j.1469-7793.1999.287ad.x

Parums, D. V. (n.d.). Editorial: Review Articles, Systematic Reviews, Meta-Analysis, and the Updated Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 Guidelines. https://doi.org/10.12659/MSM.934475

Pedersen, B. K., Ã…kerström, T. C. A., Nielsen, A. R., & Fischer, C. P. (2007). Role of myokines in exercise and metabolism. Journal of Applied Physiology, 103(3), 1093-1098. https://doi.org/10.1152/JAPPLPHYSIOL.00080.2007

Pertiwi, K. R. (2021). Potential roles of extracellular traps in the progression of coronavirus disease (covid)-19. Proceedings of the 7th International Conference on Research, Implementation, and Education of Mathematics and Sciences (ICRIEMS 2020), 528(Icriems 2020), 1-7. https://doi.org/10.2991/assehr.k.210305.001

Pozzolo, B. A., da Fonseca, V. F., Guedes, A. A., de Oliveira, G. L., Dietrich, D., Lima, E. M., Santos, T. C., Panacioni, F., Iagher, F., & Ulbrich, A. Z. (2020). Acute effect of aerobic exercise of different intensities in cytokines of university students. Revista Brasileira de Medicina Do Esporte, 26(6), 493-497. https://doi.org/10.1590/1517-869220202606223616

Sampaio, R. C., De Moura, N. R., De Barros, M. P., Hatanaka, E., Marinho Priviero, F. B., & De Moraes, C. (2019). Twice-weekly exercise training reduces oxidative stress and proinflammatory cytokine levels in elder women. Motriz. Revista de Educacao Fisica, 25(3), 1-5. https://doi.org/10.1590/s1980-6574201900030001

Seelaender, M., Lee, J. H., & Jun, H.-S. (2019). Role of myokines in regulating skeletal muscle mass and function. Frontiers in Physiology, 2019 (10). https://doi.org/10.3389/fphys.2019.00042

Seeman, M. V. Luchini C, Stubbs B, Solmi M, Veronese N. (2012). Assessing the quality of studies in meta-analyses: Advantages and limitations of the Newcastle Ottawa Scale. World Journal of Psychiatry, 2(2), 26-32

Sellami, M., Al-Muraikhy, S., Al-Jaber, H., Al-Amri, H., Al-Mansoori, L., Mazloum, N. A., Donati, F., Botre, F., & Elrayess, M. A. (2021). Age and sport intensity-dependent changes in cytokines and telomere length in elite athletes. Antioxidants, 10(7). https://doi.org/10.3390/antiox10071035

Sellami, M., Bragazzi, N. L., Aboghaba, B., & Elrayess, M. A. (2021). The impact of acute and chronic exercise on immunoglobulins and cytokines in elderly : insights from a critical review of the literature. Frontiers in Immunology, 12(April), 1-11. https://doi.org/10.3389/fimmu.2021.631873

Sellami, M., Gasmi, M., Denham, J., Hayes, L. D., Stratton, D., Padulo, J., & Bragazzi, N. (2018). Effects of acute and chronic exercise on immunological parameters in the elderly aged: Can physical activity counteract the effects of aging? Frontiers in Immunology, 9(OCT), 1-17. https://doi.org/10.3389/fimmu.2018.02187

Taherkhani, S., Suzuki, K., & Castell, L. (2020). A short overview of changes in inflammatory cytokines and oxidative stress in response to physical activity and antioxidant supplementation. Antioxidants, 9(9), 1-18. https://doi.org/10.3390/antiox9090886

Teschler, M., & Mooren, F. C. (2019). (Whole-Body) electromyostimulation, muscle damage, and immune system: a mini review. Frontiers in Physiology, 10. https://doi.org/10.3389/fphys.2019.01461

Verbickas, V., Baranauskiene, N., Eimantas, N., Kamandulis, S., Rutkauskas, S., Satkunskiene, D., Sadauskas, S., Brazaitis, M., & Skurvydas, A. (2017). Effects of sprint cycling and stretch-shortening cycle exercises on the neuromuscular, immune and stress indicators in young men. Journal of Physiology and Pharmacology, 68(1), 125-132

Vijayaraghava, A., & Radhika, K. (2014). Alteration of interferon Gamma (IFN-γ) in human plasma with graded physical activity. Journal of Clinical and Diagnostic Research, 8(6), 13-16. https://doi.org/10.7860/JCDR/2014/9502.4440

Villareal, D. T., Aguirre, L., Gurney, A. B., Waters, D. L., Sinacore, D. R., Colombo, E., Armamento-Villareal, R., & Qualls, C. (2017). Aerobic or resistance exercise, or both, in dieting obese older adults. New England Journal of Medicine (Vol. 376, Issue 20, pp. 1943-1955). https://doi.org/10.1056/nejmoa1616338

Widiastuti, I. A. E. (2020). Respon imun pada olahraga. Jurnal Kedokteran, 9(2), 165-173

Zheng, Q., Cui, G., Chen, J., Gao, H., Wei, Y., Uede, T., Chen, Z., & Diao, H. (2015). Regular exercise enhances the immune response against microbial antigens through up-regulation of toll-like receptor signaling pathways. Cellular Physiology and Biochemistry, 37(2), 735-746. https://doi.org/10.1159/000430391

Download

Share

COinS